Wei Xie

Creator 1.0: Phylogeny-Guided Stagewise Pretraining for Plant Genome Foundation Models across 1,000 Species

Creator 1.0 is a plant genome foundation model pretrained on 1,000 species using phylogeny-guided stagewise pretraining, achieving strong performance on plant-related tasks.

Interspecific hybrids reveal a deeply conserved nuclear role of EIF1A-family proteins in zygotic genome activation

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

A Long-Context Generative Foundation Model Deciphers RNA Design Principles

EVA is a long-context generative RNA model trained on 114 million sequences, achieving state-of-the-art performance in RNA design tasks and structural modeling.

Multi-Scale Kinetics Modeling and Advanced Assay for mRNA-Lipid Nanoparticle Potency Assessment

The paper develops a multi-scale kinetic model and advanced assays to assess mRNA-LNP potency by integrating mechanistic understanding with multi-omics data.

High-resolution diploid 3D genome reconstruction using Pore-C data

This paper introduces Dip3D, a method to reconstruct high-resolution diploid 3D human genomes from Pore-C data, achieving better performance than existing methods.

A Machine Learning-based Framework to Identify Type 2 Diabetes through Electronic Health Records

This paper develops a machine learning framework to identify Type 2 Diabetes cases and controls from electronic health records, achieving higher accuracy than expert-based methods.