Author

Xinyi Ma

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Physiology· 2 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:electronic health records· 1 Assay:electrophysiology· 1

Frequent Co-Authors

Aishwarya ChandrashekariD· 2 shared Kirin D. GadaiD· 2 shared Leigh Daniel PlantiD· 2 shared Meng CuiiD· 2 shared Ana Santa‐CruziD· 1 shared Anne K. YauchiD· 1 shared Anyue Cheng· 1 shared Elizabeth Scholl· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

Aishwarya ChandrashekarORCID

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Author profile →

4 papers

Recent·Most cited

PIP2 stabilizes Nav1.5 gating and links receptor signaling to cardiac late sodium current

Kirin D. Gada, Jordie M. Kamuene, Ana Santa‐Cruz, Ziyue Meng, Jenna G. Connolly, Florence Ng, Xinyi Ma, Aishwarya Chandrashekar, 徐瑜, Meng Cui, Leigh Daniel Plant

This study shows PIP2 stabilizes NaV1.5 gating and links Gq signaling to increased late sodium current, with implications for arrhythmias.

bioRxiv · Jul 3, 2026 · PreprintPhysiology

A Long-Context Generative Foundation Model Deciphers RNA Design Principles

Yanjie Huang, Guangye Lv, Anyue Cheng, Wei Xie, Mengyan Chen, Xinyi Ma, Yijun Huang, Yueyang Tang, Qingya Shi, Jiahao Wang, Junxi Wang, Junxi Wang, Yunpeng Xia, Lu Zhao, Yifang Cai, , Shuangjia Zheng

EVA is a long-context generative RNA model trained on 114 million sequences, achieving state-of-the-art performance in RNA design tasks and structural modeling.

bioRxiv · Mar 24, 2026 · PreprintMolecular Biology

Hypoxia Exacerbates Kir2.1 Channel Dysfunction in an Andersen-Tawil Syndrome Variant Through a SUMO-Dependent Mechanism

Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K. Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D. Gada, Takeharu Kawano, Meng Cui, Leigh Daniel Plant

This study shows hypoxia worsens Kir2.1 channel dysfunction in an Andersen-Tawil Syndrome variant through SUMOylation, and TAK-981 reverses this effect.

bioRxiv · Apr 25, 2025 · PreprintPhysiology

MetaGXplore: Integrating Multi-Omics Data with Graph Convolutional Networks for Pan-cancer Patient Metastasis Identification

Tao Jiang, Haiyang Jiang, Xinyi Ma, Minghao Xu, Liang Yan, Wentao Zhang

MetaGXplore uses graph convolutional networks to predict tumor metastasis likelihood and identify key genes across pan-cancer multi-omics data.

IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · Dec 3, 2024Peer-reviewedBioinformatics