Jian Wu

IGF2 mediates Hippo signaling to control liver size

This study identifies IGF2 as a mediator of Hippo signaling in liver size control, showing its role in promoting liver growth and hepatoblastoma through IGF1R activation.

Generation of Vascularized Brain Organoids to Study Neurovascular Interactions

Fusing stem cell-derived vessel organoids with cerebral organoids yields brain organoids containing vascular networks, BBB-like features and responsive microglia, with more neural progenitors than unfused controls.

Transferrin plays a central role to maintain coagulation balance by interacting with clotting factors

This study identifies transferrin as a clotting factor that modulates coagulation balance by interacting with clotting factors and antithrombin III, with implications for atherosclerosis.

Crystallizing the Parkinson’s Disease Protein LRRK2 Under Microgravity Conditions

The paper describes efforts to crystallize the Parkinson’s disease protein LRRK2 under microgravity conditions to improve diffraction quality for structure determination.