Direct targeting of the WAVE-regulatory complex and the actin cytoskeleton by the Anaplasma phagocytophilum effector, AnkA
Hannah L Burge, Shashi Prakash Singh, Jianyang Wang, Suchitra Pradhan, Katharine M Wood, Joshua W Lee, Rob Barringer, Silvia A. Synowsky, Sally L. Shirran, Patrick Joseph Moynihan, Andrew L. Lovering, Laura M. Machesky, Mark A. Jepson, John Stephen Dumler, Ian T. Cadby
This study identifies AnkA as a bacterial effector that directly targets the WAVE Regulatory Complex and actin cytoskeleton, using molecular mimicry to subvert host cell functions during infection.
bioRxiv · Sep 11, 2026 · PreprintMicrobiology