Reduced expression of PER2 protein contrbutes to β1-AA induced cardiac autophagy rhythm disorder
Pengjia Li, Jiayan feng, Jiao Guo, Jin Xue, Li Yang, Shiyuan Wen, Xiaohui Wang, Huirong Liu, li Wang
This study shows that β1-AA disrupts cardiac autophagy rhythm by reducing PER2 protein expression, which promotes mTORC1 activation and inhibits autophagy in cardiomyocytes.
bioRxiv · Dec 6, 2024 · PreprintMolecular Biology