Molecular BiologybioRxivPreprint
Reduced expression of PER2 protein contrbutes to β1-AA induced cardiac autophagy rhythm disorder
Pengjia Li, Jiayan feng, Jiao Guo…·li Wang
This study shows that β1-AA disrupts cardiac autophagy rhythm by reducing PER2 protein expression, which promotes mTORC1 activation and inhibits autophagy in cardiomyocytes.
DOI 10.1101/2024.12.06.627296