A Combinatorial mRNA Therapy for Treating Rheumatoid Arthritis and Osteoarthritis by Inhibiting Inflammation and Promoting Cartilage Regeneration
Guan Wang, Yixuan Guo, Kun Guo, Cheng Zhang, Ying Zhou, Jiayuan Xia, Jiaqing Liu, Jinyi Ren, Ahmed Osman Mohamed, Ke Tang, Xianmei Chen, Shiyu Sun, Yong Yang, Mingyun Shen, Yifan Huang, , Ang Lin
This paper develops a combinatorial mRNA therapy for arthritis that inhibits inflammation and promotes cartilage regeneration, showing efficacy in pre-clinical models.
bioRxiv · Dec 16, 2025 · PreprintImmunology