PathologybioRxivPreprint
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Phylogenomic screening reveals idsA2 loss conferring nitroimidazole cross-resistance in Mycobacterium tuberculosis
Yu Zhang, Xinchang Chen, Shiyong Wang…·Jiazhen Chen
A length- and mutation-load-corrected homoplasy screen of 1,813 MDR-TB genomes flags idsA2; its loss raises pretomanid MIC fourfold, delamanid and ethambutol twofold, via isoprenoid flux redirection.
DOI 10.64898/2026.10.19.760085