Author

Jillian Bonilla

University of Chicago

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Biochemistry· 1

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Approach:experimental assay· 1

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Haley A. HardtkeiD· 1 shared Juan L. MendozaiD· 1 shared Kailin Guo· 1 shared Mukesh Kumar Venkat RamaniiD· 1 shared Yannik Leuz· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperBiochemistry

Haley A. HardtkeORCID

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1 paper

Recent·Most cited

Graded and cross-reactive JAK-receptor interactions broaden the one-receptor, one-JAK rule

Mukesh Kumar Venkat Ramani, Juan L. Mendoza, Kailin Guo, Yannik Leuz, Jillian Bonilla, Haley A. Hardtke

The paper tests the one-receptor, one-JAK model by measuring JAK1 and TYK2 interactions with receptor ICDs, finding graded and cross-reactive binding rather than exclusive, constitutive interactions.

bioRxiv · Oct 27, 2026 · PreprintBiochemistry