BiochemistrybioRxivPreprint
Graded and cross-reactive JAK-receptor interactions broaden the one-receptor, one-JAK rule
Mukesh Kumar Venkat Ramani, Juan L. Mendoza, Kailin Guo…·Haley A. Hardtke
The paper tests the one-receptor, one-JAK model by measuring JAK1 and TYK2 interactions with receptor ICDs, finding graded and cross-reactive binding rather than exclusive, constitutive interactions.
DOI 10.64898/2026.10.24.761551