SIRT5-mediated GLS and GDH desuccinylation attenuates autophagy in MAC-T cells induced by ammonia
Hanlin Yang, Shikai Gao, Guangyang Lu, Junhui He, Jinru Dong, Xinyi Zhang, Luya Liu, Kai Zhong, Guangming Zha, Liqiang Han, Shuang Guo, Heping Li, Yueying Wang
This study shows that SIRT5 desuccinylates GLS and GDH, reducing their activity and attenuating ammonia-induced autophagy in MAC-T cells.
Cellular Signalling · Dec 17, 2024Peer-reviewedPhysiology