Functional Dichotomy of Orbitofrontal Cortex and Anterior Cingulate Cortex Subregions in Decision-Making and Brain-Body Regulation
Georgios Papageorgiou, Ken‐ichi Amemori, Daniel J. Gibson, Helen N. Schwerdt, Michelangelo Naim, Michelle C. Wang, Tomoko Yoshida, Jitendra Sharma, Urvashi M. Upadhyay, Guangyu Robert Yang, Ann M. Graybiel
This study investigates the functional roles of the caudal orbitofrontal cortex (cOFC) and pregenual anterior cingulate cortex (pACC) in macaques using multimodal recordings and electrical microstimulation, finding distinct roles in decision-making and autonomic responses.
Nature Communications · Feb 14, 2026Peer-reviewedNeuroscience