Author

Alyssa Lutservitz

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:scRNA-seq· 4 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:database / resource· 1

Frequent Co-Authors

Alec Wysoker· 4 shared James C. Nemesh· 4 shared Melissa GoldmaniD· 4 shared Steven A. McCarrolliD· 4 shared Fenna M. KrieneniD· 3 shared Guoping FengiD· 3 shared Qiangge ZhangiD· 3 shared Ricardo C.H. del RosarioiD· 3 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Alec Wysoker

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5 papers

Recent·Most cited

Sibling chimerism among microglia in marmosets

Ricardo C.H. del Rosario, Fenna M. Krienen, Qiangge Zhang, Melissa Goldman, Curtis J. Mello, Alyssa Lutservitz, Kiku Ichihara, Alec Wysoker, James C. Nemesh, Guoping Feng, Steven A. McCarroll

The paper identifies sibling-derived chimerism in microglia and macrophages across marmoset tissues using single-cell RNA-seq, showing hematopoietic origin and regional variation in brain microglia.

eLife · Aug 14, 2026Peer-reviewedNeuroscience

Concerted neuron-astrocyte gene expression declines in aging and schizophrenia

Emi Ling, James C. Nemesh, Melissa Goldman, Nolan Kamitaki, Nora M. Reed, Robert E. Handsaker, Giulio Genovese, Jonathan S. Vogelgsang, Sherif Gerges, Seva Kashin, Sulagna Dia Ghosh, John M. Esposito, Kiely Morris, Daniel Meyer, Alyssa Lutservitz, , Steven A. McCarroll

The paper identifies a neuron-astrocyte gene expression program, SNAP, that declines in aging and schizophrenia, linking it to cognitive function and genetic risk factors.

Nature · Mar 6, 2024Peer-reviewedNeuroscience

A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity

Fenna M. Krienen, Kirsten M. Levandowski, Heather Zaniewski, Ricardo C.H. del Rosario, Margaret E. Schroeder, Melissa Goldman, Martin Wienisch, Alyssa Lutservitz, Victoria F. Beja-Glasser, Cindy Chen, Qiangge Zhang, Ken Y. Chan, Katelyn X. Li, Jitendra Sharma, Dana M. McCormack, , Guoping Feng

The paper analyzes single-nucleus RNA sequencing data from marmoset brain cells to show that neuronal identity is more influenced by developmental origin than functional class.

Science Advances · Oct 12, 2023Peer-reviewedNeuroscience

Hedgehog signaling regulates neurogenesis in the larval and adult zebrafish hypothalamus

Ira Male, A. Tuba Ozacar, Rita R. Fagan, Matthew D. Loring, Meng‐Chieh Shen, Veronica A. Pace, Christine Devine, Grace Elizabeth Lawson, Alyssa Lutservitz, Rolf O. Karlstrom

This study shows that Hedgehog signaling regulates neurogenesis in the larval and adult zebrafish hypothalamus by promoting proliferation of neural precursors and maintaining a heterogeneous signaling environment.

eNeuro · Oct 26, 2020Peer-reviewedNeuroscience

Innovations in Primate Interneuron Repertoire

Fenna M. Krienen, Melissa Goldman, Qiangge Zhang, Ricardo C.H. del Rosario, Marta Florio, Robert P. Machold, Arpiar B. Saunders, Kirsten M. Levandowski, Heather Zaniewski, Benjamin Schuman, Carolyn W.‐H. Wu, Alyssa Lutservitz, Christopher D. Mullally, Nora M. Reed, Elizabeth Bien, , Steven A. McCarroll

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

Nature · Sep 30, 2020Peer-reviewedNeuroscience