Hepatocyte TEAD1 drives epithelial-stromal remodeling during cholestatic liver injury
Kumar Ar, Jeongkyung Lee, Vinny Negi, Varun Mandi, Domenic Filingeri, Joey Danvers, Rajat Pant, Samit Ghosh, Mousumi Moulik, Vijay K. Yechoor
This study shows hepatocyte TEAD1 promotes fibrosis and inflammation in cholestatic liver injury but not bile acid metabolism, suggesting it as a therapeutic target in PSC.
bioRxiv · May 26, 2026 · PreprintPathology