Restoring Aquaporin-4 alleviates molecular and motor phenotypes in zQ175 mouse model of Huntington disease
Hongshuai Liu, Zichen Ding, Yadi Wang, Helen Moniz, Yuguo Li, Yuxiao Ouyang, Chang Liu, John Andersen, Jun Hua, Jiadi Xu, Wenzhen Duan
This study shows that restoring aquaporin-4 in a Huntington disease mouse model improves glymphatic function and reduces disease-related molecular and motor phenotypes.
bioRxiv · Sep 25, 2026 · PreprintNeuroscience