Author

John Randolph

University of Rochester Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Alison Hobbins· 3 shared Jennetta W. HammondiD· 3 shared Julia M. GranatoiD· 3 shared Angela StoutiD· 2 shared Carlos J. Reyes-SepúlvedaiD· 2 shared Nina Silver· 2 shared Allison T. RyaniD· 1 shared Harris A. GelbardiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Alison Hobbins

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of SEZ6L2 disrupts synaptic architecture and drives progressive behavioral deficits

Julia M. Granato, Nina Silver, Alison Hobbins, John Randolph, Angela Stout, Harris A. Gelbard, Jenny M Gunnersen, Samuel Mackenzie, Patricia M. White, Jennetta W. Hammond

This study characterizes Sez6l2 knockout mice, showing behavioral and synaptic deficits, and compares them to Sez6 triple knockout mice, highlighting SEZ6L2's non-redundant role in brain function.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

Genetic background shapes SEZ6L2 autoimmunity and reveals coordinated immune responses linked to neurological dysfunction

Carlos J. Reyes-Sepúlveda, John Randolph, Julia M. Granato, Alison Hobbins, Jennetta W. Hammond

This study shows that genetic background affects SEZ6L2 autoimmunity, with SJL mice showing stronger immune responses and neurological dysfunction compared to C57BL/6 mice.

bioRxiv · Apr 3, 2026 · PreprintImmunology

Sez6L2 autoimmunity induces cerebellar ataxia in mice

Carlos J. Reyes-Sepúlveda, Julia M. Granato, John Randolph, Allison T. Ryan, Alison Hobbins, Angela Stout, Nina Silver, Herman Li, Jennetta W. Hammond

This study shows that Sez6L2 autoimmunity in mice causes cerebellar ataxia, with antibodies and T cells targeting Sez6L2 leading to mobility impairments and brain inflammation.

Journal of Neuroinflammation · Nov 25, 2025Peer-reviewedNeuroscience