Harris A. Gelbard

Dual kinase inhibition provides early clues to restoration of neuroimmune homeostasis in an AAV-haSyn model of Parkinsons disease

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

Loss of SEZ6L2 disrupts synaptic architecture and drives progressive behavioral deficits

This study characterizes Sez6l2 knockout mice, showing behavioral and synaptic deficits, and compares them to Sez6 triple knockout mice, highlighting SEZ6L2's non-redundant role in brain function.

Dynamics of Neutrophilia at the Neurovascular Unit Arising from Repeated Pulmonary Inflammation

This study investigates how repeated pulmonary inflammation leads to neutrophil dynamics at the neurovascular unit, showing increased neutrophilia and microglial activation in the brain.

Pericytes Repair Engineered Defects in the Basement Membrane to Restore Barrier Integrity in an in vitro Model of the Blood-Brain Barrier.

Hybrid Amyloid Quantum Dot Nanoassemblies to Probe Neuroinflammatory Damage

The paper develops a quantum dot mimetic to study the role of amyloid-beta oligomers in neuroinflammatory responses in neuronal and glial cells.

URMC-099 Prophylaxis Prevents Hippocampal Vascular Vulnerability and Synaptic Damage in an Orthopedic Model of Delirium Superimposed on Dementia

The paper investigates the effects of URMC-099 in preventing vascular and synaptic damage in a mouse model of delirium superimposed on dementia.

A Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Dysregulation of the Neurovascular Unit Relevant to Brain Inflammation

This study uses a SARS-CoV-2 biomimetic to investigate how BBB dysregulation may lead to neuroinflammation without direct viral infection.

The Sez6 family inhibits complement at the level of the C3 convertase.

This study shows that Sez6 family members inhibit C3 convertase activity in both classical and alternative complement pathways.

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis

This study investigates complement-dependent synapse loss and microgliosis in EAE mice, finding that C3 knockout reduces synapse loss and microglial activation.

The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

This study shows that URMC-099 prevents surgery-induced microglial activation and cognitive decline in a mouse model of PND without affecting bone healing.