IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
Hua Jiang, Sam P. Limsuwannarot, Kayla R. Kulhanek, Aastha Pal, Ossama Labiad, Lea Wenting Rysavy, Ada Wong, Leon Su, Sarah M. Cavender, Johnathon Soro, Stefano Testa, Heather Anne N. Ogana, Deepa Waghray, Pingdong Tao, Kevin M. Jude, , Anusha K. Kalbasi
The paper shows that T cells engineered with IL-9R have better tissue infiltration, stemness, and anti-tumor activity compared to those with an orthogonal IL-9 receptor, due to stronger and more specific JAK/STAT signaling.
Immunity · Nov 21, 2025Peer-reviewedImmunology