A Cytokine Receptor Signaling Atlas Reveals How STAT Mosaics Fine-Tune T Cell Function
Pingdong Tao, Ruchir Rastogi, Hua Jiang, Yang Zhao, Leon Su, Kevin M. Jude, Anshul Bharat Kundaje, K. Christopher García
A fully orthogonal IL-2 receptor platform isolates 36 cytokine receptors in T cells; receptor-specific STAT combinations specify distinct fates, and STAT3-dominant programs give curative antitumor responses.
bioRxiv · Aug 24, 2026 · PreprintImmunology✦ In-depth digest