Catalytically distinct IDH1 mutants tune phenotype severity in tumor models
Mowaffaq Adam Ahmed Adam, Mikella Robinson, Ashley V. Schwartz, Grace A. Wells, An D. Hoang, Elene Albekioni, Cecilia Gallo, Grace Chao, Joi L. Weeks, Giovanni Quichocho, Uduak Z. George, Carrie Danielle House, Şevin Turcan, Christal Dyane Sohl
This study shows that IDH1 R132Q mutants produce more D2HG than R132H mutants, leading to more aggressive tumors through distinct epigenetic and transcriptomic changes.
bioRxiv · Apr 22, 2024 · PreprintGenomics