GenomicsbioRxivPreprint
Catalytically distinct IDH1 mutants tune phenotype severity in tumor models
Mowaffaq Adam Ahmed Adam, Mikella Robinson, Ashley V. Schwartz…·Christal Dyane Sohl
This study shows that IDH1 R132Q mutants produce more D2HG than R132H mutants, leading to more aggressive tumors through distinct epigenetic and transcriptomic changes.
DOI 10.1101/2024.04.22.590655