Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes
Yue Liu, Shilpa J Rao, Ian Hoskins, Michael M. Geng, Qiuxia Zhao, Jonathan Chacko, Vighnesh Ghatpande, Kangsheng Qi, Logan Persyn, Jun Wang, Dinghai Zheng, Yochen Zhong, Dayea Park, Elif Sarinay Cenik, Vikram Agarwal, , Can Cenik
The paper analyzes ribosome profiling data to show translation efficiency covariation (TEC) is conserved across human and mouse cells, revealing gene functions not evident from RNA or protein co-expression.
Nature Biotechnology · Jul 25, 2025Peer-reviewedBioinformatics