Jun Wang

An RNA-centric atlas of human cell cycle regulation

The paper defines an RNA-centric landscape of human cell cycle control by profiling various RNA features and identifies key RNA elements involved in cell cycle regulation.

NeuroPilot: Longitudinal intravital neural imaging across scales and modalities through an agentic platform

NeuroPilot converts heterogeneous intravital neural recordings into stable population activity maps, enabling behavioral decoding and structured neural dynamics analysis across behavioral states.

Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity

This study identifies an early neutrophil interferon program that predicts resistance to anti-PD1 therapy and limits durable anti-tumor immunity.

Cardiomyocytes upregulated PD-L1 expression to alleviate cardiac injury induced by irradiation combined with anti-PD-1 antibody: an in vitro and in vivo study

This study shows irradiation increases PD-L1 in cardiomyocytes, which may protect against cardiac injury by limiting inflammation and CD8 T-cell activity in mice.

Dissecting the TMEM132A-EGFR Dependency to Unlock Translational Therapeutic Opportunities for Pan-Solid Tumor

This paper identifies TMEM132A as a pan-cancer target that stabilizes EGFR and drives lipid synthesis, and develops a nanobody to inhibit this interaction, showing antitumor activity in resistant models.

Sleep dynamics and epileptogenesis following Kainic acid in epilepsy-susceptible (DBA/2J) and epilepsy-resistant (C57BL/6) mice

This study compares sleep and seizure dynamics in epilepsy-susceptible DBA/2J and resistant C57BL/6 mice after Kainic acid treatment, finding baseline sleep abnormalities and circadian rhythm issues in DBAs contribute to worse seizures.

The in vivo inhibitory function of the MHC-I alpha3 domain/CD8alpha interaction

This study identifies the MHC-I alpha3 domain-CD8 interaction as an inhibitory pathway that restrains CD8+ T-cell activation and maintains tolerance in vivo.

Integration of spatial single-cell proteomics and spatial metabolomics reveals tumor microenvironment predictive of immunotherapy response in mucosal melanoma

Molecular Glue-Induced Homodimerization Drives Targeted CRBN Autodegradation

This paper introduces LJY-3-60, a molecular glue that induces CRBN homodimerization and autodegradation, providing a tool for controlled protein degradation.

Autophagy Cargo Profiles in Skeletal Muscle during Starvation and Exercise

The paper develops a method to isolate autophagosomes from mice and uses proteomics to analyze cargo profiles in skeletal muscle during starvation and exercise, identifying distinct cargo selection patterns.

Computational Discovery of Core Protein - Targeted Therapeutics Against Ginger Wilt Pathogen Ralstonia solanacearum

The paper identifies antibacterial agents targeting Ralstonia solanacearum using computational methods and experimental validation, finding several compounds with strong inhibitory effects.

Predicting the translation efficiency of messenger RNA in mammalian cells

The paper predicts translation efficiency (TE) of mRNA in mammalian cells using a deep learning model trained on ribosomal profiling data across multiple cell types.

Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes

The paper analyzes ribosome profiling data to show translation efficiency covariation (TEC) is conserved across human and mouse cells, revealing gene functions not evident from RNA or protein co-expression.

Genome-Wide Insights into the Genes and Pathways Shaping Human Foveal Development

This study identifies 123 genome-wide significant loci associated with foveal pit depth, revealing new biological pathways and genes involved in human foveal development.

An Adipose mTORC1 Effector Links Nutrient-induced Ribosomal Protein Translation to Lifespan in Drosophila

YAP engages RIF1 to dampen replication stress-induced DNA damage in human squamous cell carcinoma.

This study identifies YAP's interaction with RIF1 in squamous cell carcinoma, showing it reduces replication stress-induced DNA damage through non-transcriptional mechanisms.

A spectrum of altered non-rapid eye movement sleep in schizophrenia

This study replicates group-level sleep EEG differences in schizophrenia and shows increased patient-to-patient variability in NREM metrics, with medication and age-related effects contributing to this heterogeneity.

CodonBERT: Large Language Models for mRNA Design and Optimization

CodonBERT is a large language model for mRNA design and optimization that outperforms previous methods on a flu vaccine dataset.

Predicting regional somatic mutation rates using DNA motifs

The paper predicts somatic mutation rates in 13 cancers using DNA motifs and identifies impactful motifs and cancer-specific regions for classification.

Hippo-deficient cardiac fibroblasts differentiate into osteochondroprogenitors

This study shows that Hippo-deficient cardiac fibroblasts differentiate into osteochondroprogenitors and interact with macrophages, promoting fibrosis through CSF1 signaling.

The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models

The paper introduces the EN-TEx resource, which provides personal epigenomes and variant-impact models across multiple tissues, revealing allele-specific loci and their associations with GWAS loci.

A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer

This study identifies an optimal strategy for drug repositioning using LINCS data and applies it to discover new therapeutics for liver cancer, showing homoharringtonine as a promising candidate.

Large-scale association analyses identify host factors influencing human gut microbiome composition

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

Predicting unrecognized enhancer-mediated genome topology by an ensemble machine learning model

LoopPredictor predicts enhancer-promoter loops in cell types lacking long-range contact maps using ensemble machine learning and multi-omics features.

Next-generation sequencing based hospital outbreak investigation yields insight into Klebsiella aerogenes population structure and determinants of carbapenem resistance and virulence

The paper uses whole-genome sequencing to investigate a hospital outbreak of carbapenem-resistant Klebsiella aerogenes, identifying genetic factors contributing to resistance and virulence.

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

This study shows that SDHB deficiency reprograms energy metabolism and protects against high fat diet-induced obesity by restoring glucose and lipid metabolism.

Wide sampling of natural diversity identifies novel molecular signatures of C4 photosynthesis

The paper identifies novel molecular signatures of C4 photosynthesis by analyzing transcriptomes from eighteen independent origins of C4 plants, revealing shared and new metabolic pathways and gene expression responses to low CO2.

Genome sequencing of the perciform fish Larimichthys crocea provides insights into stress adaptation

This study sequenced the genome of the large yellow croaker to understand its adaptation to environmental stress, finding expanded gene families and novel regulatory networks involved in stress response.