Loss of Syndecan-3 Drives a Pro-inflammatory, EndMT-prone Phenotype in Aortic Valve Endothelial Cells
George I. Ezeokeke, Guy C. Bedford, Joseph JC Stroschein, Anael Roig-Gicquel, Isaac B. Hilton, Kathryn Jane Grande-Allen
This study identifies syndecan-3 as a regulator of inflammation and EndMT in aortic valve endothelial cells, showing its role in suppressing NF-kappaB activation and mesenchymal transition.
bioRxiv · Sep 8, 2026 · PreprintPathology