Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease
Hwoi Chan Kwon, Adrian M. Eiden, Joshua Li, Martin MacKinnon, Joshua B. Garfinkel, Sarah Hooper, Yanling Liu, Mark T. Nelson, Alan P. Koretsky, Amreen Mughal
This study shows that electro-calcium uncoupling in endothelial cells precedes neurodegeneration and cognitive decline in 5xFAD mice.
bioRxiv · Jan 27, 2026 · PreprintNeuroscience