Amreen Mughal

This study shows that electro-calcium uncoupling in endothelial cells precedes neurodegeneration and cognitive decline in 5xFAD mice.

The paper characterizes primary cilia and centriole organization in mouse and human brain microvasculature, revealing interspecies differences and their potential role in sensing microenvironmental signals.

This study shows that pathogenic tau peptides reduce endothelial calcium signaling and vasodilation in brain microvessels, impairing cerebral blood flow.

The paper demonstrates that brain capillary endothelial cells and pericytes express functional KATP channels that regulate membrane potential and cerebral blood flow through adenosine signaling.

The paper identifies TRPA1 channels in brain capillary endothelial cells as key initiators of neurovascular coupling by generating retrograde signals that dilate upstream arterioles.