Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules
Samantha J Cassell, Weiyan Li, Simon Krautwald, Maryam Khoshouei, Yan Tony Lee, Joyce Hou, Wendy Guan, Stefan Peukert, Wilhelm Andreas Weihofen, Jonathan R. Whicher
The paper determines the structures of SK2 channels in different states and identifies how apamin and small molecules modulate their gating.
eLife · Dec 4, 2025Peer-reviewedPharmacology & Toxicology