Maryam Khoshouei

The paper determines the structures of SK2 channels in different states and identifies how apamin and small molecules modulate their gating.

This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.

This study determines the cryo-EM structure of LqhIT bound to NavPas, revealing its interaction with a glycan at the pore domain and its mechanism of action.

This study elucidates how BACH1 is regulated by SCFFBXO22 and SCFFBXL17 through structural changes in FBXO22 and modifications in BACH1's BTB domain, affecting its ubiquitylation and stability.