Author

Samantha J Cassell

Novartis (Switzerland)ORCID 0009-0003-3533-8482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jonathan R. WhicheriD· 2 shared Maryam KhoshoueiiD· 2 shared Wilhelm Andreas WeihofeniD· 2 shared Callum J. DicksoniD· 1 shared Christopher J. SchwaleniD· 1 shared Joyce Hou· 1 shared Simon KrautwaldiD· 1 shared Stefan PeukertiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

Jonathan R. WhicherORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyeLifePeer-reviewedDec 4, 2025

Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Samantha J Cassell, Weiyan Li, Simon Krautwald…·Jonathan R. Whicher

The paper determines the structures of SK2 channels in different states and identifies how apamin and small molecules modulate their gating.

3 citations

structural biologyexperimental assay

𝕏 PostBluesky

BiophysicsStructurePeer-reviewedAug 23, 2024

Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels

Swastik Phulera, Callum J. Dickson, Christopher J. Schwalen…·Wilhelm Andreas Weihofen

This study determines the cryo-EM structure of LqhIT bound to NavPas, revealing its interaction with a glycan at the pore domain and its mechanism of action.

6 citations

structural biologyexperimental assay

𝕏 PostBluesky