The impact of seizures on REM sleep and the cholinergic pedunculopontine nucleus in a mouse model of Dravet Syndrome
Krystal Santiago-Colon, Chandni Rana, Brandon A. Toth, Julia A. Kravchenko, Joseph Barden, Isabella VanHorn, Alex Jack, Alexander Hollier, Rida Qureshi, Hudson Haberland, Juan Disla, Nagham Eldroubi, Saif Siddiqui, Sophie Erb-Watson, Christian R. Burgess, , Joanna Mattis
This study shows seizures impair REM sleep by disrupting cholinergic neurons in the pedunculopontine nucleus in a mouse model of Dravet Syndrome.
bioRxiv · Feb 18, 2026 · PreprintNeuroscience