The polyamine naphthyl-acetyl spermine trihydrochloride (NASPM) lacks specificity for Ca2+-permeable AMPA receptors and suppresses seizure like activity in human brain tissue by inhibition of NMDA receptors.
Alice Podestà, Laura Monni, Franziska Arnold, Julia Arnold, Sara Bertelli, Ran Xu, Julia Onken, Ulrich‐Wilhelm Thomale, Thilo Kalbhenn, Matthias Simon, Thomas Sauvigny, Henrik Alle, Andrew J.R. Plested, Martin Holtkamp, Jörg RP Geiger, Pawel Fidzinski
This study shows NASPM inhibits NMDA receptors rather than CP-AMPARs in human brain tissue, challenging its use as a specific CP-AMPAR inhibitor and questioning its therapeutic potential.
bioRxiv · May 14, 2025 · PreprintNeuroscience