Jörg R. P. Geiger

This study compares the effects of AMPA receptor inhibitors on seizure-like events in murine and human brain slices, finding species-specific differences in drug efficacy.

The paper investigates electrical signaling between mid-capillary pericytes and endothelial cells in the neurovascular unit, showing syncytial coupling and its role in transmitting seizure-associated signals without relying on VGCCs.

This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.

The paper characterizes neuronal and synaptic diversity in human layer 2-3 pyramidal neurons across individuals, finding that neuronal physiology varies with laminar depth while synaptic properties are consistent.

This study shows NASPM inhibits NMDA receptors rather than CP-AMPARs in human brain tissue, challenging its use as a specific CP-AMPAR inhibitor and questioning its therapeutic potential.

The paper demonstrates that gamma-oscillation plasticity in the hippocampus is mediated by parvalbumin interneurons through specific metabotropic signaling pathways.

The paper shows how coherent neural oscillations in Drosophila create filters that promote quiescence over navigation by hierarchically overriding locomotion-promoting networks.

NOSA is an open-source software for analyzing voltage imaging data, offering tools to improve signal processing and identify temporal interactions in neural activity.

This paper introduces a high-throughput in-vitro multipatch setup for analyzing microcircuits in human brain tissue, enabling the study of synaptic connections across multiple neurons.

The paper identifies delta oscillations in Drosophila's R2 network that regulate sleep, showing synchronization depends on NMDARs and input pathways, and disrupting this mechanism abolishes oscillations and impairs sleep.