Targeting catecholate siderophore systems enables precision depletion of gut enterobacteria during colitis
Grant J. Norton, Anna M. Dudek, Romana Raphaela Gerner, Chuchu Guo, Vanessa Castillo, Felix A. Argueta, Connor J. Beebout, Ghazal Kanyabi, Julia Drushell, Gregory T. Walker, Chia-Yun Hsu, Shingo Bessho, Sean‐Paul Nuccio, Hiutung Chu, Karsten Zengler, , Manuela Raffatellu
This study shows that targeting catecholate siderophore systems reduces AIEC colonization in colitis by immunization, preserving gut microbiome composition.
bioRxiv · Oct 5, 2026 · PreprintMicrobiology