Host response against SARS-CoV-2 infection is impacted by allosteric modulation of cholinergic and purinergic receptors
Victoire Perraud, Guilherme Dias de Melo, Marco Cecchini, Lauriane Kergoat, Julien Lannoy, Jean‐Pierre Changeux, Hervé Bourhy, Florence Larrous
Ivermectin's protection in SARS-CoV-2-infected hamsters depended partly on both α7 nicotinic and P2X4 receptors; in co-cultures its effects were α7nAChR-independent, and P2X4 blockade prevented CXCL10 induction at 48 hpi.
bioRxiv · Oct 26, 2026 · PreprintPathology✦ In-depth digest