Coronary Artery Disease Transcriptomics Reveals Two Drivers of the Endothelial Cell SR-BI Expression and LDL Transport that Underlie Atherosclerosis
Linzhang Huang, Yibin Huang, Jiayu Zhu, Jun Peng, Kenian Chen, Ken L. Chambliss, Qinbo Zhou, Ryan J. Vela, DENNIS BURNS, Bo Li, Matthias Peltz, Yun Hua Fang, Lin Xu, Chieko Mineo, Philip W. Shaul
This study identifies two factors, hypercholesterolemia and disturbed blood flow, that upregulate endothelial SR-BI to drive LDL transport and atherosclerosis.
bioRxiv · Aug 6, 2026 · PreprintCell Biology