Jun Xu

Distinct RNA-RNA spatial interaction sub-networks of transcription factors in hepatic cells

The paper uses RIC-seq and integrates multi-omics data to classify transcription factors into two clusters based on RNA-RNA spatial interactions and their genomic and clinical features.

Vector2Variant: Discovery of Genetic Associations from ML Derived Representations without Phenotype Engineering

Vector2Variant transforms high-dimensional data into genome-wide association scans without predefined phenotypes, identifying genetic associations and novel variants linked to diseases.

EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression

This study identifies REEP2 as a key mediator of EMT-driven membrane trafficking in lung cancer, promoting metastasis through enhanced ER-to-Golgi transport.

Astrocyte-specific secretome profiling reveals its correlation with neurological disorders

The paper develops a secretome profiling method for astrocytes and identifies proteins involved in disease-related toxicity and neuroprotection.

In vivo Chemical Reprogramming of Astrocytes into Functional Neurons

This study shows that small molecules can convert astrocytes into functional neurons in the adult mouse brain, which can integrate into the brain and express neuron-specific markers.

Fishing for New Bt Receptors in Diamondback Moth

The paper identifies two glucosinolate sulfatases, GSS1 and GSS2, as binding targets for the Bt toxin Cry1Bd in diamondback moth and shows their role in toxin toxicity.