TCR/ITK signaling via mTOR tunes CD8+ T cell homeostatic proliferation, metabolism, and anti-tumor effector function
Weishan Huang, Junjie Luo, Avery August
The paper shows that ITK negatively regulates CD8+ T cell homeostatic proliferation, metabolism, and anti-tumor effector function through mTOR, challenging the notion that stronger TCR signals always enhance these processes.
bioRxiv · Jun 29, 2018 · PreprintImmunology