LplA-mediated rescue of lethal myopathy and cardiomyopathy in mitochondrial lipoylation-deficient mammalian caused by Lipt1
Junru Yu, Zhijuan Hu, Ziwei Liu, Runqing Yang, Anping Zeng
This study uses AAV-delivered LplA to rescue lethal mitochondrial lipoylation defects in Lipt1-deficient mice, improving survival, motor function, and cardiac health.
bioRxiv · Nov 3, 2026 · PreprintCell Biology