Peptide inhibitors recognize prefusion viral fusion proteins with heterogeneous stoichiometry and rapid kinetics
Revansiddha H. Katte, Junyu Liu, Yufan He, Bhishem Thakur, Xiao Huang, Jared J. Lindenberger, Wang Xu, Narendra Kumar Gonepudi, Yang Han, Katarzyna Janowska, Robert J. Edwards, Priyamvada Acharya, Maolin Lu
This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.
bioRxiv · Sep 15, 2026 · PreprintMicrobiology