Priyamvada Acharya

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.

This study uses single-molecule FRET to show that gp41-directed antibodies stabilize or open the prefusion-closed state of HIV-1 Env, revealing two neutralization mechanisms.

This study identifies two sequential conformational gates in HIV-1 Env that control fusion peptide release and host cell entry initiation.

This paper determines the crystal structures of 19b Fab in complex with HIV-1 V3 loop peptides, revealing the epitope and binding mode of the antibody.

This study investigates the structural and antigenic diversity of Henipavirus and Parahenipavirus glycoproteins using cryo-EM and crystal structures, revealing new epitopes and insights for vaccine development.

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

The paper shows that affinity maturation enhances HIV-1 recognition by reshaping antibody encounter state pathways through germline-somatic residue synergy.

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

This study visualizes the conformational changes of the HIV-1 fusion peptide during CD4-induced Env opening, showing it remains antibody accessible despite Env opening.

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.

The paper determines cryo-EM structures of Langya virus fusion protein in pre- and post-fusion states, revealing structural differences and a potential mechanism for fusion initiation.

The paper describes new features and applications of Spotiton, a cryoEM sample vitrification instrument, showing it produces high-quality specimens with no apparent sample damage.