Author
Jian Yu
Aaron Diamond AIDS Research CenterORCID 0000-0001-8604-4538Unclaimed ORCID profile · follow to get notified of new preprints
Additional preprints under this name without ORCID
Biology Disciplines
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2023-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 44 mutual co-author links7 papers
Recent·Most cited
- MicrobiologybioRxivPreprint
A Monoclonal Antibody Panel to Track Antigenic Evolution of SARS-CoV-2 JN.1 Subvariants
Hsiang Hong, Madeline Wu, Sue Chong…·David D. Ho
The paper develops a monoclonal antibody panel to track antigenic evolution of SARS-CoV-2 JN.1 subvariants and identifies differences in antibody-evasion profiles between JN.1 and BA.3.2 lineages.
1 citation - MicrobiologyeLifePeer-reviewed
Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization
Wang Xu, Narendra Kumar Gonepudi, Junyu Liu…·Maolin Lu
This study uses single-molecule FRET to show that gp41-directed antibodies stabilize or open the prefusion-closed state of HIV-1 Env, revealing two neutralization mechanisms.
DOI 10.7554/elife.110887 - MicrobiologybioRxivPreprint
A Panel of Human Monoclonal Antibodies for Tracking the Antigenic Evolution of Influenza H5N1 Clade 2.3.4.4b
Hsiang Hong, Nicholas C. Morano, Madeline Wu…·David D. Ho
This study generates 19 human monoclonal antibodies to track antigenic evolution of H5N1 clade 2.3.4.4b, identifying epitope-specific neutralization patterns and antigenic differences between viral genotypes.
2 citations - MicrobiologyNature CommunicationsPeer-reviewed
Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2
Qian Wang, Yicheng Guo, Ryan G. Casner…·David D. Ho
This study optimizes a human monoclonal antibody to enhance its neutralization of SARS-CoV-2 variants, including subvariants XEC and LP.8.1, through structural analysis and engineering.
15 citationstop 1% - ImmunologyStructurePeer-reviewed
Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan
Nicholas C. Morano, Yicheng Guo, Jordan E. Becker…·Peter D. Kwong
The paper reports the cryo-EM structure of H5N1 hemagglutinin showing an auto-glycan from N169 binds the receptor-binding site, highlighting auto-glycan recognition in zoonotic transmission.
13 citationstop 2% - MicrobiologyNaturePeer-reviewed
Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike
Qian Wang, Yicheng Guo, Liyuan Liu…·David D. Ho
This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.
191 citationstop 1%