Crucial role for Sodium Hydrogen Exchangers in SGLT2 inhibitor-induced arterial relaxations
E. A. Forrester, B.-A. Benitez-Angeles, K. E. Redford, T. Rosenbaum, G. W. Abbott, V. Barrese, K. A. Dora, A. Albert, D. Dannesboe, I. Salles-Crawley, T. A. Jepps, I. A. Greenwood
This study shows SGLT2 inhibitors relax mesenteric arteries via CGRP release from sensory nerves, mediated by NHE1 inhibition, but not renal arteries.
bioRxiv · Dec 5, 2023 · PreprintPhysiology