Identification of human CD4+ T cell populations with distinct antitumor activity
M. H. Nelson, H. M. Knochelmann, S. R. Bailey, L. W. Huff, J. S. Bowers, K. Majchrzak, M. M. Wyatt, M. P. Rubinstein, S. Mehrotra, M. I. Nishimura, K. Armeson, P. G. Giresi, M. J. Zilliox, H. E. Broxmeyer, C. M. Paulos
The paper identifies human CD4+ T cell populations with distinct antitumor activity, showing CD26high T cells are epigenetically and transcriptionally different from Th17 cells and are more effective in tumor therapy.
bioRxiv · Dec 31, 2019Immunology