M. M. Wyatt

This study shows that varying levels of PI3Kδ pathway inhibition affect T cell stemness, with higher stemness improving cancer immunotherapy outcomes in multiple tumor models.

This study shows that reducing TCR and co-stimulation signal strength in Th17 cell manufacturing enhances their metabolic fitness and antitumor efficacy in mesothelioma models.

This study shows that CpG-mediated expansion with B cells enhances CD8+ T cell tumor immunity by inducing a unique proteomic signature and specific surface markers.

The paper expands murine tumor-infiltrating lymphocytes ex vivo in IL-2 and compares their phenotypes to human TILs from oral cavity cancer patients.

The paper identifies human CD4+ T cell populations with distinct antitumor activity, showing CD26high T cells are epigenetically and transcriptionally different from Th17 cells and are more effective in tumor therapy.

This paper shows that inhibiting PI3Kδ with CAL-101 enhances CD8+ T cell memory and antitumor efficacy in both murine and human models.