Mesenchymal Stromal Cells regulate human Hematopoietic Stem Cell survival, engraftment and regeneration via PGE2/cAMP signaling pathway
S. S. N. A. MUDDINENI, C. Katz-Even, A. Zipin-Roitman, D. Rasoulouniriana, D. S. Roy, R. Aborgies, E. Weizman, K. Beider, R. Chen, G. Hershkovitz, Y. Shulman, N. Solomon, Y. Raz, C. Waskow, A. Nagler, M. Milyavsky
This study shows that mesenchymal stromal cells protect human hematopoietic stem cells from radiation damage via the PGE2/cAMP signaling pathway, enhancing their survival and engraftment.
bioRxiv · Nov 9, 2023Cell Biology