R. Chen

Bridging scale-up to transplantation: pluripotent stem cell-derived pancreatic islet encapsulation in emulsion-generated high concentration alginate beads

This study develops a scalable encapsulation method for pluripotent stem cell-derived pancreatic islets, showing improved cell recovery and in vivo functionality during transplantation.

Immunological evaluation in African Green Monkeys of two nasal vaccine candidates to induce a broad immunity against coronaviruses

This study evaluates two nasal coronavirus vaccines in African Green Monkeys, showing they induce cross-reactive immunity and neutralizing responses against SARS-CoV-2 and related coronaviruses.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Cell type-specific inhibitory modulation of sound processing in the auditory thalamus

The paper investigates how two types of inhibitory neurons in the thalamic reticular nucleus differentially modulate sound processing in the auditory thalamus.

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages

This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention

This study shows licochalcone A suppresses breast cancer growth by targeting SREBP1-dependent lipogenesis and inflammation.

Finite element analysis of a neural implant for cytostatic hypothermia and a novel heat management system

This paper presents a computational analysis of a neural implant system for cytostatic hypothermia, showing it can achieve uniform brain cooling without overheating the body.

An effector XopL enhances ethylene biosynthesis to promote Xanthomonas fragariae infection in strawberry

This study identifies XopL as an effector that enhances ethylene biosynthesis in strawberry, promoting Xanthomonas fragariae infection by stabilizing FveACO9 and increasing ACO activity.

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

CMTM6 maintains B cell intrinsic CD40 expression to regulate anti-tumor immunity

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Mesenchymal Stromal Cells regulate human Hematopoietic Stem Cell survival, engraftment and regeneration via PGE2/cAMP signaling pathway

This study shows that mesenchymal stromal cells protect human hematopoietic stem cells from radiation damage via the PGE2/cAMP signaling pathway, enhancing their survival and engraftment.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Ultrahigh Resolution Lipid Mass Spectrometry Imaging of High-Grade Serous Ovarian Cancer Mouse Models

This study uses high-resolution MSI to analyze lipid changes in ovarian cancer mouse models, identifying biomarkers for diagnosis.

Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

This study identifies distinct roles of H3K36 dimethylation and trimethylation in DNA double-strand break repair via NHEJ and HR in yeast and humans.

Repressor sequestration activates translation of germ granule localized mRNA

This study shows that Drosophila embryonic germ granules activate nanos mRNA translation by sequestering translational repressors, rather than changing translation rate or efficiency.

Characterization of Ralstonia pseudosolanacearum diversity and screening host resistance to manage bacterial wilt in South Asia

The paper surveys RSSC pathogens in Bangladesh and Nepal, characterizes their genetic diversity, and screens crop accessions for resistance to bacterial wilt.

Commensal microbiome dysbiosis elicits IL-8 signaling to drive fibrotic skin disease

The paper investigates the role of commensal microbiome dysbiosis in keloid fibrosis, finding elevated IL-8 signaling drives collagen accumulation and fibroblast migration.

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

The oral pathogen Porphyromonas gingivalis resists the antimicrobial peptide LGL13K and evades the D-enantiomer by synonymous mutations in hagA

This study identifies synonymous mutations in hagA that confer resistance to DGL13K in P. gingivalis by altering mRNA structure and reducing HagA expression, without affecting mRNA levels.

NbPTR1 confers resistance against Pseudomonas syringae pv. actinidiae in kiwifruit

This study identifies NbPTR1 as a resistance gene against Pseudomonas syringae pv. actinidiae in kiwifruit by introducing it into susceptible cultivars to confer resistance.

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

Butyrate Protects against SARS-CoV-2-induced Tissue Damage in Golden Hamsters.

This study shows butyrate protects against SARS-CoV-2-induced tissue damage in golden hamsters by enhancing antiviral immunity and reducing oxidative stress.

Fitness Tradeoffs of Multidrug Efflux Pumps in Escherichia coli K-12 in Acid or Base, and with Aromatic Phytochemicals

This study examines the fitness tradeoffs of multidrug efflux pumps in E. coli under acidic or basic conditions and in the presence of aromatic phytochemicals, showing that lipophilic non-acidic molecules select against AcrAB-TolC without benefiting other pumps.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

Dysregulated Platelet Function in Patients with Post-Acute Sequelae of COVID-19

This study examines platelet function and thrombotic risk in PASC patients, finding dysregulated platelet responses and reduced thrombosis under shear conditions.

Towards revealing the transient dynamics in plant biomass allocation pattern

The paper develops a heuristic approach to study transient plant biomass allocation patterns and finds periodic changes in leaf and stem biomass in response to plant dimensions.

Quantifying cell viability through organelle ratiometric probing

This paper introduces a fluorescent probe, PCV-1, and an analytical assay called organelle ratiometric probing (ORP) to quantify cell viability at the single-cell level using super-resolution microscopy.

Histone divergence in Trypanosoma brucei results in unique alterations to nucleosome structure

This study characterizes the structure of nucleosome core particles from Trypanosoma brucei, revealing unique histone alterations that affect DNA and protein interactions.