Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19
M. Reyes, M. R. Filbin, R. P. Bhattacharyya, A. Sonny, A. Mehta, K. Billman, K. R. Kays, M. Pinilla-Vera, M. E. Benson, MGH COVID-19 Collection & Processing Team, L. A. Cosimi, D. T. Hung, B. D. Levy, A.-C. Villani, M. Sade-Feldman, , N. Hacohen
The paper identifies a regulatory myeloid program, MS1, associated with sepsis mortality and up-regulated in severe COVID-19, showing its immunosuppressive role and cytokine-dependent induction.
bioRxiv · Sep 2, 2020Immunology