A. Mehta

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response

The paper identifies immune hubs in lung cancer that are associated with better responses to PD-1-blockade immunotherapy and contain stem-like CD8 T cells.

Magnetically Controlled Cyclic Microscale Deformation of in vitro Cancer Invasion Models

This study uses magnetic actuation to apply cyclic mechanical deformation to tumor spheroids in 3D matrices, showing increased cancer cell invasion and intracellular calcium responses.

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling

This study identifies a non-canonical ITGB2 signaling pathway that activates EGFR and RAS/MAPK/ERK in SCLC, leading to aggressive tumor behavior and resistance to EGFR inhibitors.

Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

This study shows that anti-RBDwt titers correlate with neutralizing antibody levels against multiple SARS-CoV-2 variants and proposes a method to improve immunomonitoring precision and throughput.

Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade

The paper identifies plasma proteomic biomarkers that predict non-response to PD1 blockade in melanoma patients and links them to tumor microenvironment biology.

Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19

The paper identifies a regulatory myeloid program, MS1, associated with sepsis mortality and up-regulated in severe COVID-19, showing its immunosuppressive role and cytokine-dependent induction.

Diversity and Distribution of a Novel Genus of Hyperthermophilic Aquificae Viruses Encoding a Proof-reading Family-A DNA Polymerase

The paper describes novel hyperthermophilic Aquificae viruses with unique genomic features and proposes a new genus based on their distinct replication strategy and gene-sharing networks.

Plasma-derived exosomal analysis and deconvolution enables prediction and tracking of melanoma checkpoint blockade response

This paper uses plasma-derived exosomal RNA to predict and track melanoma response to immune checkpoint inhibitors by analyzing tumor and immune signatures.

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli are Altered with Age

The paper shows that aged hematopoietic stem cells exhibit a myeloid-biased transcriptional response to inflammation, which is linked to Klf5, Ikzf1, and Stat3.