P. C. Blainey

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

This study identifies KatG catalase deficiency in INH-resistant M. tuberculosis as a factor contributing to hyper-susceptibility to bedaquiline.

This paper introduces bCARMEN, a high-throughput system for rapid, multiplexed bacterial pathogen detection and antibiotic resistance gene identification using CRISPR-Cas13 and droplet microfluidics.

The paper identifies a regulatory myeloid program, MS1, associated with sepsis mortality and up-regulated in severe COVID-19, showing its immunosuppressive role and cytokine-dependent induction.

The paper identifies conserved transcriptional programs in lung mononuclear phagocytes across diseases using a unified framework and applies it to characterize disease-associated populations.

The paper discovers a hydrogenotrophic methanogenesis pathway in Verstraetearchaeota and the Wood-Ljungdahl pathway in Desulfurococcales, suggesting an ancient origin of hydrogenotrophic methanogenesis and a later adaptation to methylotrophic methanogenesis.

This paper presents a microfluidic system for sorting and profiling immune cell subsets using RNA-seq, demonstrating its utility in identifying cell-specific disease signatures in lupus patients.

This paper develops a high-throughput screening system for discovering synergistic drug combinations and applies it to identify new antibiotic synergies against E. coli.

The paper introduces a method combining molecular enrichment with FACS to efficiently sample rare dendritic cell populations in single-cell RNA-Seq libraries.

This paper introduces a microfluidic-based mini-metagenomic method to extract novel microbial genomes from complex environmental samples, revealing 29 new genomes with diverse metabolic pathways and SNP distributions.