BiophysicsbioRxiv
Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human NaV1.7 Channel
K. Ngo, D. L. Mateos, Y. Han…·I. Vorobyov
This study uses computational modeling to investigate how protoxin-2 binds to different states of the hNaV1.7 channel, identifying key residues and lipid interactions that contribute to its selectivity.
DOI 10.1085/jgp.202313368